Product Data Sheet
25-Hydroxycholesterol-d6
Catalog No. A71774
25-Hydroxycholesterol-d6 is a deuterium-labeled form of 25-Hydroxycholesterol, a metabolite of cholesterol synthesized and released by macrophages upon Toll-like receptor (TLR) activation. This compound serves as a selective and potent inhibitor of immunoglobulin A (IgA) production in B cells, with an effective concentration (EC50) of approximately 65 nM. Its unique labeling makes it a valuable tool for tracing cholesterol metabolism and studying immune response mechanisms in various research applications.
Chemical Information
| Catalog Num | A71774 |
|---|---|
| M. Wt | 408.69 |
| Formula | C27H40D6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 88247-69-2 |
| Synonyms | 25-OHC-d6 |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C |
Biological Activity
| Description | 25-Hydroxycholesterol-d6 is a deuterium-labeled form of 25-Hydroxycholesterol, a metabolite of cholesterol synthesized and released by macrophages upon Toll-like receptor (TLR) activation. This compound serves as a selective and potent inhibitor of immunoglobulin A (IgA) production in B cells, with an effective concentration (EC50) of approximately 65 nM. Its unique labeling makes it a valuable tool for tracing cholesterol metabolism and studying immune response mechanisms in various research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
