Product Data Sheet
5-Hydroxymethylcytosine
Catalog No. A71904
5-Hydroxymethylcytosine (5hmC) is an oxidized derivative of 5-methylcytosine found within mammalian DNA. Generated through an enzymatic process involving the Ten-eleven translocation (TET) enzymes TET1, TET2, and TET3, 5hmC serves as an important marker for investigating the dynamic processes of DNA demethylation and gene transcription. Its presence is particularly significant in the study of conditions such as non-small cell lung cancer, neurodegenerative diseases like Alzheimer’s and Parkinson’s, and various hematological malignancies, including acute myeloid leukemia and myelodysplastic syndromes.
Chemical Information
| Catalog Num | A71904 |
|---|---|
| M. Wt | 141.13 |
| Formula | C5H7N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1123-95-1 |
| Synonyms | 5hmC |
| SMILES | O=C1N=CC(CO)=C(N1)N |
Biological Activity
| Description | 5-Hydroxymethylcytosine (5hmC) is an oxidized derivative of 5-methylcytosine found within mammalian DNA. Generated through an enzymatic process involving the Ten-eleven translocation (TET) enzymes TET1, TET2, and TET3, 5hmC serves as an important marker for investigating the dynamic processes of DNA demethylation and gene transcription. Its presence is particularly significant in the study of conditions such as non-small cell lung cancer, neurodegenerative diseases like Alzheimer’s and Parkinson’s, and various hematological malignancies, including acute myeloid leukemia and myelodysplastic syndromes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
