Product Data Sheet
7α-Hydroxy-4-cholesten-3-one-d7
Catalog No. A72204
7α-Hydroxy-4-cholesten-3-one-d7 is a deuterium-labeled analogue of 7α-Hydroxy-4-cholesten-3-one, which serves as an intermediate in bile acid synthesis from cholesterol. This compound acts as an agonist for the pregnane X receptor (PXR) and is recognized as a biomarker for bile acid loss, irritable bowel syndrome, and various conditions linked to impaired bile acid biosynthesis. Additionally, 7α-Hydroxy-4-cholesten-3-one is a physiological substrate for the enzyme CYP8B1, making it valuable for research in metabolic and gastrointestinal disorders.
Chemical Information
| Catalog Num | A72204 |
|---|---|
| M. Wt | 407.68 |
| Formula | C27H37D7O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2260669-17-6 |
| Synonyms | |
| SMILES | C[C@H](CCCC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)CC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O |
Biological Activity
| Description | 7α-Hydroxy-4-cholesten-3-one-d7 is a deuterium-labeled analogue of 7α-Hydroxy-4-cholesten-3-one, which serves as an intermediate in bile acid synthesis from cholesterol. This compound acts as an agonist for the pregnane X receptor (PXR) and is recognized as a biomarker for bile acid loss, irritable bowel syndrome, and various conditions linked to impaired bile acid biosynthesis. Additionally, 7α-Hydroxy-4-cholesten-3-one is a physiological substrate for the enzyme CYP8B1, making it valuable for research in metabolic and gastrointestinal disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
