Product Data Sheet
CL-385319
Catalog No. A72249
CL-385319 is an N-substituted piperidine compound that targets the H5N1 avian influenza A virus, demonstrating inhibitory activity against infection. It exhibits an IC50 of 27.03±2.54 μM in Madin-Darby canine kidney cells (MDCK) and displays low cytotoxicity with a CC50 of 1.48 mM. CL-385319 effectively inhibits the entry of pseudoviruses carrying various H5N1 strains, although no effect is observed on VSV-G pseudotyped particles. Notably, mutations M24A in HA1 and F110S in HA2 confer resistance to CL-385319, suggesting the significance of these residues for binding efficacy. This compound is suitable for research applications concerning influenza virus entry mechanisms and antiviral drug development.
Chemical Information
| Catalog Num | A72249 |
|---|---|
| M. Wt | 354.77 |
| Formula | C15H19ClF4N2O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1210501-46-4 |
| Synonyms | |
| SMILES | O=C(NCCN1CCCCC1)C2=CC(C(F)(F)F)=CC(F)=C2.[H]Cl |
Biological Activity
| Description | CL-385319 is an N-substituted piperidine compound that targets the H5N1 avian influenza A virus, demonstrating inhibitory activity against infection. It exhibits an IC50 of 27.03±2.54 μM in Madin-Darby canine kidney cells (MDCK) and displays low cytotoxicity with a CC50 of 1.48 mM. CL-385319 effectively inhibits the entry of pseudoviruses carrying various H5N1 strains, although no effect is observed on VSV-G pseudotyped particles. Notably, mutations M24A in HA1 and F110S in HA2 confer resistance to CL-385319, suggesting the significance of these residues for binding efficacy. This compound is suitable for research applications concerning influenza virus entry mechanisms and antiviral drug development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
