Product Data Sheet
XR5944
Catalog No. A72392
XR5944 is a potent topoisomerase inhibitor that targets DNA, demonstrating significant anti-tumor activity. It effectively inhibits the activities of both topoisomerase I and II, showcasing impressive potency across various cell lines, with IC50 values ranging from 0.04 to 0.4 nM. XR5944 remains effective in overcoming atypical drug resistance mechanisms, including cells overexpressing P-glycoprotein and multidrug resistance-related proteins. This compound has shown remarkable anti-tumor efficacy in preclinical models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in multiple cases. XR5944 is valuable for research on colon and lung cancer biological processes.
Chemical Information
| Catalog Num | A72392 |
|---|---|
| M. Wt | 586.69 |
| Formula | C34H34N8O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 343247-32-5 |
| Synonyms | |
| SMILES | O=C(C1=CC=CC2=NC3=CC=CC(C)=C3N=C21)NCCNCCNCCNC(C4=CC=CC5=NC6=CC=CC(C)=C6N=C54)=O |
Biological Activity
| Description | XR5944 is a potent topoisomerase inhibitor that targets DNA, demonstrating significant anti-tumor activity. It effectively inhibits the activities of both topoisomerase I and II, showcasing impressive potency across various cell lines, with IC50 values ranging from 0.04 to 0.4 nM. XR5944 remains effective in overcoming atypical drug resistance mechanisms, including cells overexpressing P-glycoprotein and multidrug resistance-related proteins. This compound has shown remarkable anti-tumor efficacy in preclinical models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in multiple cases. XR5944 is valuable for research on colon and lung cancer biological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
