Product Data Sheet
ML395
Catalog No. A72987
ML395 is a potent and selective allosteric inhibitor of phospholipase D2, demonstrating significant antiviral activity. With a cellular IC50 value for PLD2 of 360 nM and an IC50 value for PLD1 exceeding 30,000 nM, it exhibits remarkable selectivity. ML395 possesses favorable pharmacokinetic profiles in vitro and superior physicochemical properties compared to other phospholipase inhibitors. Its efficacy has been validated in cell-based assays against various strains of the influenza virus, including H1, H3, H5, and H7, making it a valuable tool for antiviral research.
Chemical Information
| Catalog Num | A72987 |
|---|---|
| M. Wt | 443.54 |
| Formula | C26H29N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1638957-17-1 |
| Synonyms | |
| SMILES | O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(CC4=CC=CN=C4)CN5)C5=O |
Biological Activity
| Description | ML395 is a potent and selective allosteric inhibitor of phospholipase D2, demonstrating significant antiviral activity. With a cellular IC50 value for PLD2 of 360 nM and an IC50 value for PLD1 exceeding 30,000 nM, it exhibits remarkable selectivity. ML395 possesses favorable pharmacokinetic profiles in vitro and superior physicochemical properties compared to other phospholipase inhibitors. Its efficacy has been validated in cell-based assays against various strains of the influenza virus, including H1, H3, H5, and H7, making it a valuable tool for antiviral research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
