Product Data Sheet
YM-355179 fumarate
Catalog No. A72992
YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions.
Chemical Information
| Catalog Num | A72992 |
|---|---|
| M. Wt | 618.65 |
| Formula | C33H35FN4O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 887647-69-0 |
| Synonyms | |
| SMILES | O=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NC=C(C)C=C5O)=O)CC\4.O=C(O)/C=C/C(O)=O |
Biological Activity
| Description | YM-355179 fumarate is a selective antagonist of the C-C chemokine receptor type 3 (CCR3), targeting eosinophil-related allergic inflammatory diseases. This compound effectively inhibits the binding of CCL11 and CCL5 to CCR3-expressing cells, exhibiting IC50 values of 7.6 nM and 24 nM, respectively. Functional assays demonstrate that YM-355179 fumarate inhibits CCL11-induced intracellular Ca(2+) influx, chemotaxis, and eosinophil degranulation, with IC50 values of 8.0 nM, 24 nM, and 29 nM, respectively. This makes it a valuable tool for researchers studying allergic inflammation and related conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
