Product Data Sheet
H-0106 dihydrochloride
Catalog No. A73154
H-0106 dihydrochloride is a selective inhibitor of Rho-associated kinase (ROCK), primarily targeting the modulation of intraocular pressure (IOP). This compound exhibits significant IOP-lowering activity, as demonstrated in primate models. Research indicates that while H-0106 dihydrochloride effectively inhibits the ROCK enzyme, the relationship between ROCK inhibition and IOP reduction may not be straightforward, warranting further investigation into its mechanisms of action in ocular health.
Chemical Information
| Catalog Num | A73154 |
|---|---|
| M. Wt | 426.79 |
| Formula | C16H22Cl3N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1011465-90-9 |
| Synonyms | |
| SMILES | O=S(C1=CC=CC2=C1C(Cl)=CN=C2)(N3[C@H](CNCCCC3)C)=O.[H]Cl.[H]Cl |
Biological Activity
| Description | H-0106 dihydrochloride is a selective inhibitor of Rho-associated kinase (ROCK), primarily targeting the modulation of intraocular pressure (IOP). This compound exhibits significant IOP-lowering activity, as demonstrated in primate models. Research indicates that while H-0106 dihydrochloride effectively inhibits the ROCK enzyme, the relationship between ROCK inhibition and IOP reduction may not be straightforward, warranting further investigation into its mechanisms of action in ocular health. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
