Product Data Sheet
Lifirafenib hydrochloride
Catalog No. A73200
Lifirafenib hydrochloride is a reversible inhibitor of the B-RAFV600E mutation, exhibiting significant antitumor activity in solid tumors, including melanoma, thyroid cancer, and low-grade serous ovarian cancer. This compound demonstrates selective cytotoxicity by preferentially targeting cancer cells harboring B-RAFV600E and EGFR mutations or amplifications. In preclinical studies, Lifirafenib has been shown to inhibit tumor growth in a dose-dependent manner, resulting in partial and complete tumor regression in animal models, making it a valuable tool for cancer research applications.
Chemical Information
| Catalog Num | A73200 |
|---|---|
| M. Wt | 514.88 |
| Formula | C25H18ClF3N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2025320-97-0 |
| Synonyms | BGB-283 hydrochloride |
| SMILES | O=C1NC2=NC=CC(OC3=CC=C(O[C@@]4([H])[C@]5([H])[C@@H]4C6=NC7=CC=C(C(F)(F)F)C=C7N6)C5=C3)=C2CC1.Cl |
Biological Activity
| Description | Lifirafenib hydrochloride is a reversible inhibitor of the B-RAFV600E mutation, exhibiting significant antitumor activity in solid tumors, including melanoma, thyroid cancer, and low-grade serous ovarian cancer. This compound demonstrates selective cytotoxicity by preferentially targeting cancer cells harboring B-RAFV600E and EGFR mutations or amplifications. In preclinical studies, Lifirafenib has been shown to inhibit tumor growth in a dose-dependent manner, resulting in partial and complete tumor regression in animal models, making it a valuable tool for cancer research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
