Product Data Sheet
A 62176 hydrochloride
Catalog No. A73241
A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development.
Chemical Information
| Catalog Num | A73241 |
|---|---|
| M. Wt | 417.82 |
| Formula | C20H17ClFN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 111783-54-1 |
| Synonyms | |
| SMILES | O=C(C1=CN2C3=C(OC4=C2C(C1=O)=CC(F)=C4N5CCC(C5)N)C=CC=C3)O.Cl |
Biological Activity
| Description | A 62176 hydrochloride is a potent inhibitor of DNA topoisomerase II, demonstrating significant activity in disrupting purine synthesis in cancer cells. By interacting with G-quadruplex structures, A 62176 hydrochloride reduces c-MYC mRNA expression and displaces nucleosomes from the non-template strand of rDNA. This mechanism leads to DNA damage that necessitates repair via BRCA1/2-mediated homologous recombination and DNA-PK-mediated non-homologous end-joining pathways, highlighting its potential applications in cancer research and therapeutic development. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
