Product Data Sheet
H2-005
Catalog No. A73309
H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders.
Chemical Information
| Catalog Num | A73309 |
|---|---|
| M. Wt | 440.54 |
| Formula | C24H32N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1060478-12-7 |
| Synonyms | |
| SMILES | O=C(C1=C(C2=C(N1CCC(C)C)N=CC(NC(CC)CC)=C2)NC(C3=CC=CO3)=O)OC |
Biological Activity
| Description | H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2), effectively reducing triacylglycerol synthesis in both hepatocytes and preadipocytes. This compound demonstrates significant inhibition of triacylglycerol biosynthesis in HepG2 hepatocytes and 3T3-L1 preadipocytes. Additionally, H2-005 substantially inhibits lipid droplet formation in 3T3-L1 cells when used in conjunction with a DGAT1 inhibitor. This reagent is valuable for research related to DGAT2-mediated lipid metabolism and potential therapeutic strategies for metabolic disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
