Product Data Sheet
ATB 429
Catalog No. A73353
ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation.
Chemical Information
| Catalog Num | A73353 |
|---|---|
| M. Wt | 361.46 |
| Formula | C16H11NO3S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 915798-75-3 |
| Synonyms | |
| SMILES | O=C(C1=CC(N)=CC=C1O)OC2=CC=C(C3=CSSC3=S)C=C2 |
Biological Activity
| Description | ATB-429 is a novel H2S-releasing derivative of mesalamine, targeting the modulation of pain and inflammation associated with irritable bowel syndrome (IBS). It exhibits significant anti-nociceptive and anti-inflammatory activities by releasing hydrogen sulfide, effectively reducing hypersensitivity in colorectal distension models in both healthy and postcolitic rats. ATB-429 attenuates abdominal withdrawal responses, suppresses spinal c-Fos mRNA expression, and down-regulates colonic cyclooxygenase-2 and interleukin-1β mRNA levels—actions not seen with mesalamine alone. The compound's effects are mediated through ATP-sensitive K+ (KATP) channels, indicating its potential as a therapeutic agent for painful intestinal disorders linked to inflammation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
