Product Data Sheet
AMG-151
Catalog No. A73367
AMG-151 is a glucokinase agonist that enhances insulin secretion and lowers fasting plasma glucose (FPG) levels. In clinical evaluations, AMG-151 demonstrated a significant dose-response effect compared to placebo, indicating its potential in managing metabolic disorders. However, its use is associated with a higher incidence of hypoglycemia and hypertriglyceridemia. This compound holds promise for further research into the treatment of type 1 diabetes and related metabolic conditions.
Chemical Information
| Catalog Num | A73367 |
|---|---|
| M. Wt | 454.53 |
| Formula | C20H18N6O3S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1138669-65-4 |
| Synonyms | ARRY-403 |
| SMILES | O[C@H](CO)C1=NSC(NC2=NC=C(C=C2OC3=CC=CN=C3C)SC4=NC=CC=C4)=N1 |
Biological Activity
| Description | AMG-151 is a glucokinase agonist that enhances insulin secretion and lowers fasting plasma glucose (FPG) levels. In clinical evaluations, AMG-151 demonstrated a significant dose-response effect compared to placebo, indicating its potential in managing metabolic disorders. However, its use is associated with a higher incidence of hypoglycemia and hypertriglyceridemia. This compound holds promise for further research into the treatment of type 1 diabetes and related metabolic conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
