Product Data Sheet
IST-622
Catalog No. A73466
IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research.
Chemical Information
| Catalog Num | A73466 |
|---|---|
| M. Wt | 828.81 |
| Formula | C44H44O16 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 128201-92-3 |
| Synonyms | 6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin |
| SMILES | CCOCCC(OC1=C(C=CC=C2O[C@H]3[C@@H]([C@]4([H])[C@](O[C@H](C5=CC=CC=C5)O4)([H])[C@H](O3)C)O[C@@H]6[C@@H]([C@H]([C@H]([C@H](O6)C)O)OC)O)C2=C(OC(C7=C(C)C=CC(O8)=C79)=O)C9=C1C8=O)=O |
Biological Activity
| Description | IST-622 is an endogenous metabolite exhibiting significant anti-tumor activity through the inhibition of cancer cell growth. It demonstrates potent growth inhibitory effects against various mouse tumor models, including P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, and Colon 26 and 38 adenocarcinomas. Additionally, IST-622 is effective in human tumor xenograft models, notably large cell lung carcinoma and gastric adenocarcinoma. In vitro studies reveal an IC50 for P388 leukemia that is over 20 times lower than conventional treatments, underscoring its potential as a therapeutic agent in oncology research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
