Product Data Sheet
A-57696
Catalog No. A73488
A-57696 is a cholecystokinin (CCK) antagonist that selectively targets cortical CCK-B receptors with an IC50 of 25 nM. It functions as a competitive antagonist, effectively reversing CCK8-induced pancreatic alpha-amylase secretion and phosphatidylinositol degradation, while also inhibiting CCK8-induced gallbladder contraction. Notably, A-57696 exhibits partial agonist activity at CCK-B/gastrin receptors on NCI-H345 cells, eliciting up to 80% of the maximal CCK8 response. This compound serves as a valuable tool in research focused on gastrointestinal physiology and the modulation of CCK-related pathways.
Chemical Information
| Catalog Num | A73488 |
|---|---|
| M. Wt | 693.79 |
| Formula | C35H47N7O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 125598-87-0 |
| Synonyms | |
| SMILES | C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(NN)=O)=O)CC(O)=O)=O)CC(C)C)=O)NC(OC(C)(C)C)=O)C=2C=3C(NC2)=CC=CC3 |
Biological Activity
| Description | A-57696 is a cholecystokinin (CCK) antagonist that selectively targets cortical CCK-B receptors with an IC50 of 25 nM. It functions as a competitive antagonist, effectively reversing CCK8-induced pancreatic alpha-amylase secretion and phosphatidylinositol degradation, while also inhibiting CCK8-induced gallbladder contraction. Notably, A-57696 exhibits partial agonist activity at CCK-B/gastrin receptors on NCI-H345 cells, eliciting up to 80% of the maximal CCK8 response. This compound serves as a valuable tool in research focused on gastrointestinal physiology and the modulation of CCK-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
