Product Data Sheet
12-Oxo-leukotriene B4
Catalog No. A73601
12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies.
Chemical Information
| Catalog Num | A73601 |
|---|---|
| M. Wt | 334.45 |
| Formula | C20H30O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 136696-10-1 |
| Synonyms | 12-Oxo-LTB4 |
| SMILES | CCCCC/C=C\CC(/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O)=O |
Biological Activity
| Description | 12-Oxo-leukotriene B4 is an endogenous metabolite and an important intermediate in the lipoxygenase-catalyzed metabolism of arachidonic acid. This compound plays a crucial role in the biosynthesis of leukotriene B4 and is involved in inflammatory responses. It stimulates intracellular calcium levels in human neutrophils with an EC50 of 33 nM and promotes neutrophil migration with an EC50 of 170 nM. Its biological activity makes it a valuable tool for research in inflammation and immune response studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
