Product Data Sheet
7α,24(S)-Dihydroxycholesterol
Catalog No. A73695
7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde.
Chemical Information
| Catalog Num | A73695 |
|---|---|
| M. Wt | 418.65 |
| Formula | C27H46O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 245523-67-5 |
| Synonyms | (3β,7α,24S)-Cholest-5-ene-3,7,24-triol |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@H](O)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=C[C@H]3O)C |
Biological Activity
| Description | 7α,24(S)-Dihydroxycholesterol is an endogenous metabolite that functions as a selective ligand for liver X receptors (LXR), specifically binding to the ligand binding domains of both LXRα and LXRβ. This compound plays a significant role in cholesterol metabolism and homeostasis, making it valuable for research applications in lipid biology and metabolic disorders. Its synthesis involves a series of transformations starting from E-α,β-enone and using Arsonium ylide and J-tert-butyldimethylsilyloxy-bisnor-5-cholenaldehyde. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
