Product Data Sheet
Cilobradine
Catalog No. A73752
Cilobradine is an HCN channel blocker primarily targeting the hyperpolarization-activated cyclic nucleotide-gated channels HCN1, HCN2, HCN3, and HCN4. It exhibits significant biological activity by decreasing heart rate, effectively reducing endogenous If current in mouse sinoatrial node cells with an IC50 of 0.62 μM. Cilobradine can lower heart rates from 600 bpm to 200 bpm in a dose-dependent manner, with an ED50 of 1.2 mg/kg. However, at doses exceeding 5 mg/kg, Cilobradine may induce arrhythmias characterized by periodic fluctuations between T waves and P waves, making it a valuable tool for cardiovascular research.
Chemical Information
| Catalog Num | A73752 |
|---|---|
| M. Wt | 482.61 |
| Formula | C28H38N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 147541-45-5 |
| Synonyms | Cilo |
| SMILES | O=C1N(C[C@@H]2CN(CCC3=CC=C(OC)C(OC)=C3)CCC2)CCC4=CC(OC)=C(OC)C=C4C1 |
Biological Activity
| Description | Cilobradine is an HCN channel blocker primarily targeting the hyperpolarization-activated cyclic nucleotide-gated channels HCN1, HCN2, HCN3, and HCN4. It exhibits significant biological activity by decreasing heart rate, effectively reducing endogenous If current in mouse sinoatrial node cells with an IC50 of 0.62 μM. Cilobradine can lower heart rates from 600 bpm to 200 bpm in a dose-dependent manner, with an ED50 of 1.2 mg/kg. However, at doses exceeding 5 mg/kg, Cilobradine may induce arrhythmias characterized by periodic fluctuations between T waves and P waves, making it a valuable tool for cardiovascular research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
