Product Data Sheet
YM-44781 free acid
Catalog No. A73776
YM-44781 free acid is a potent antagonist targeting neuropeptide receptors, specifically the NK(1) and NK(2) receptors. It demonstrates strong binding affinity for the NK(2) receptor (pKi = 9.94) and noteworthy affinity for the NK(1) receptor (pKi = 9.09). This compound has been shown to significantly inhibit bladder contractions induced by selective NK(1) receptor agonists, making it a valuable tool in research focused on neuropeptide signaling and bladder function.
Chemical Information
| Catalog Num | A73776 |
|---|---|
| M. Wt | 568.51 |
| Formula | C31H32Cl2FN3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 173943-29-8 |
| Synonyms | |
| SMILES | O=C(N(CC(CCN1CCC2(CC1)NC(CC3=C2C=CC=C3)=O)C4=CC=C(C(Cl)=C4)Cl)C)C5=CC=C(C=C5)F |
Biological Activity
| Description | YM-44781 free acid is a potent antagonist targeting neuropeptide receptors, specifically the NK(1) and NK(2) receptors. It demonstrates strong binding affinity for the NK(2) receptor (pKi = 9.94) and noteworthy affinity for the NK(1) receptor (pKi = 9.09). This compound has been shown to significantly inhibit bladder contractions induced by selective NK(1) receptor agonists, making it a valuable tool in research focused on neuropeptide signaling and bladder function. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
