Product Data Sheet
R892
Catalog No. A73799
R892 is a selective bradykinin B1 receptor antagonist that demonstrates significant antagonistic activity with pA2 values of 8.8 and 8.6 for human and rabbit B1 receptors, respectively. With an ID50 of 2.8 nM for B1 receptors and >600 nM for B2 receptors, R892 exhibits a strong selectivity profile and lacks agonistic properties. Furthermore, R892 is resistant to degradation by aminopeptidase and kininase II (ACE), showcasing its metabolic stability. This compound serves as a valuable tool for research applications investigating bradykinin receptor signaling and related physiological functions.
Chemical Information
| Catalog Num | A73799 |
|---|---|
| M. Wt | 1154.36 |
| Formula | C58H83N13O12 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 229030-05-1 |
| Synonyms | |
| SMILES | C(=O)([C@H]1N(C([C@@H](NC([C@H](CCCCN)NC(C)=O)=O)CCCNC(=N)N)=O)CCC1)N2[C@H](C(NCC(N([C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@H](CC4=CC5=C(C=C4)C=CC=C5)C(N[C@@H]([C@H](CC)C)C(O)=O)=O)=O)CO)=O)C)=O)=O)CCC2 |
Biological Activity
| Description | R892 is a selective bradykinin B1 receptor antagonist that demonstrates significant antagonistic activity with pA2 values of 8.8 and 8.6 for human and rabbit B1 receptors, respectively. With an ID50 of 2.8 nM for B1 receptors and >600 nM for B2 receptors, R892 exhibits a strong selectivity profile and lacks agonistic properties. Furthermore, R892 is resistant to degradation by aminopeptidase and kininase II (ACE), showcasing its metabolic stability. This compound serves as a valuable tool for research applications investigating bradykinin receptor signaling and related physiological functions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
