Product Data Sheet
CS-003
Catalog No. A73836
CS-003 is a potent triple neurokinin receptor antagonist, targeting NK1, NK2, and NK3 receptors with Ki values of 2.3 nM, 0.54 nM, and 0.74 nM, respectively, in human tissues. It demonstrates superior inhibitory activity against guinea pig neurokinin receptors as well, with Ki values of 5.2 nM, 0.47 nM, and 0.71 nM. CS-003 significantly inhibits inositol phosphate formation related to the neurokinin signaling of substance P, neurokinin A, and neurokinin B. Furthermore, it effectively reduces citric acid-induced cough, exhibiting enhanced activity compared to selective neurokinin receptor antagonists, making it valuable for research in neurogenic respiratory disorders.
Chemical Information
| Catalog Num | A73836 |
|---|---|
| M. Wt | 710.11 |
| Formula | C34H39Cl3N2O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 216776-73-7 |
| Synonyms | |
| SMILES | O=S1C2(CCN(CC2)CC[C@@]3(C4=CC(Cl)=C(C=C4)Cl)CN(CCO3)C(C5=CC(OC)=C(C(OC)=C5)OC)=O)C6=CC=CC=C6C1.Cl |
Biological Activity
| Description | CS-003 is a potent triple neurokinin receptor antagonist, targeting NK1, NK2, and NK3 receptors with Ki values of 2.3 nM, 0.54 nM, and 0.74 nM, respectively, in human tissues. It demonstrates superior inhibitory activity against guinea pig neurokinin receptors as well, with Ki values of 5.2 nM, 0.47 nM, and 0.71 nM. CS-003 significantly inhibits inositol phosphate formation related to the neurokinin signaling of substance P, neurokinin A, and neurokinin B. Furthermore, it effectively reduces citric acid-induced cough, exhibiting enhanced activity compared to selective neurokinin receptor antagonists, making it valuable for research in neurogenic respiratory disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
