Product Data Sheet
AZD4877 hydrochloride
Catalog No. A73892
AZD4877 hydrochloride is a selective inhibitor of the microtubule motor protein kinesin-5 (KSP), primarily utilized for its anti-tumor properties. By inhibiting dynein's function, AZD4877 disrupts mitotic spindle assembly, activating the spindle assembly checkpoint and resulting in cell cycle arrest during mitosis. This disruption may lead to apoptosis in rapidly dividing cancer cells, while potentially reducing the risk of peripheral neuropathy commonly associated with other microtubule-targeted therapies. AZD4877 plays a critical role in ensuring the formation of bipolar spindles and the accurate segregation of sister chromatids during cell division.
Chemical Information
| Catalog Num | A73892 |
|---|---|
| M. Wt | 540.12 |
| Formula | C28H34ClN5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 758722-12-2 |
| Synonyms | |
| SMILES | O=C(N(CCCN)C(C1=NC(SN=C2C)=C2C(N1CC3=CC=CC=C3)=O)C(C)C)C4=CC=C(C)C=C4.[H]Cl |
Biological Activity
| Description | AZD4877 hydrochloride is a selective inhibitor of the microtubule motor protein kinesin-5 (KSP), primarily utilized for its anti-tumor properties. By inhibiting dynein's function, AZD4877 disrupts mitotic spindle assembly, activating the spindle assembly checkpoint and resulting in cell cycle arrest during mitosis. This disruption may lead to apoptosis in rapidly dividing cancer cells, while potentially reducing the risk of peripheral neuropathy commonly associated with other microtubule-targeted therapies. AZD4877 plays a critical role in ensuring the formation of bipolar spindles and the accurate segregation of sister chromatids during cell division. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
