Product Data Sheet
H-0104 dihydrochloride
Catalog No. A73899
H-0104 dihydrochloride is a selective inhibitor of Rho-associated protein kinase (ROCK), targeting pathways involved in ocular pressure regulation. This compound has been shown to effectively lower intraocular pressure (IOP) in preclinical models, specifically in monkey eyes. It warrants further investigation to elucidate the mechanisms underlying its IOP-lowering effects, which may not solely rely on ROCK inhibition. H-0104 dihydrochloride is valuable for research applications focused on glaucoma and other conditions associated with elevated IOP.
Chemical Information
| Catalog Num | A73899 |
|---|---|
| M. Wt | 457.21 |
| Formula | C15H20BrCl2N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 913636-88-1 |
| Synonyms | |
| SMILES | C[C@@H]1N(CCCNC1)S(=O)(C2=CC=CC3=C2C(Br)=CN=C3)=O.[H]Cl.[H]Cl |
Biological Activity
| Description | H-0104 dihydrochloride is a selective inhibitor of Rho-associated protein kinase (ROCK), targeting pathways involved in ocular pressure regulation. This compound has been shown to effectively lower intraocular pressure (IOP) in preclinical models, specifically in monkey eyes. It warrants further investigation to elucidate the mechanisms underlying its IOP-lowering effects, which may not solely rely on ROCK inhibition. H-0104 dihydrochloride is valuable for research applications focused on glaucoma and other conditions associated with elevated IOP. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
