Product Data Sheet
AKR1C2/3-IN-2
Catalog No. A73938
AKR1C2/3-IN-2 is a selective inhibitor targeting the aldo-keto reductase 1C3 (AKR1C3). This compound effectively inhibits AKR1C3-mediated production of testosterone and induction of prostate-specific antigen (PSA), thereby interfering with the endocrine functions of prostate cancer cells. Its selectivity for AKR1C3 over other aldo-keto reductases suggests its potential utility in addressing drug-resistant prostate cancer. Additionally, AKR1C2/3-IN-2 shows no inhibitory activity against cyclooxygenase (COX) isomerases, reinforcing its specificity in prostate cancer research applications.
Chemical Information
| Catalog Num | A73938 |
|---|---|
| M. Wt | 244.29 |
| Formula | C15H16O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 56600-73-8 |
| Synonyms | |
| SMILES | O=C(C(CC)C1=CC=C2C=C(C=CC2=C1)OC)O |
Biological Activity
| Description | AKR1C2/3-IN-2 is a selective inhibitor targeting the aldo-keto reductase 1C3 (AKR1C3). This compound effectively inhibits AKR1C3-mediated production of testosterone and induction of prostate-specific antigen (PSA), thereby interfering with the endocrine functions of prostate cancer cells. Its selectivity for AKR1C3 over other aldo-keto reductases suggests its potential utility in addressing drug-resistant prostate cancer. Additionally, AKR1C2/3-IN-2 shows no inhibitory activity against cyclooxygenase (COX) isomerases, reinforcing its specificity in prostate cancer research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
