Product Data Sheet
KB 5666
Catalog No. A73943
KB 5666 is a benzoxazine derivative that inhibits lipid peroxidation, demonstrating significant neuroprotective effects. This compound effectively protects CA1 neurons from post-ischemic damage when administered shortly before or after ischemia, exhibiting a dose-dependent response within one hour of treatment. Furthermore, KB 5666 preserves microtubule-associated protein 2 immunoreactivity in CA1 pyramidal cells and maintains [3H]PDBu binding activity post-ischemia. These properties make KB 5666 a valuable reagent for studying ischemic conditions and their cellular consequences in neurological research.
Chemical Information
| Catalog Num | A73943 |
|---|---|
| M. Wt | 456.53 |
| Formula | C24H32N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 131916-69-3 |
| Synonyms | |
| SMILES | C=CCN1CCN(CC1)C2=NC(OCCCCC)=C3C=CC=CC3=N2.O=C(/C=C/C(O)=O)O |
Biological Activity
| Description | KB 5666 is a benzoxazine derivative that inhibits lipid peroxidation, demonstrating significant neuroprotective effects. This compound effectively protects CA1 neurons from post-ischemic damage when administered shortly before or after ischemia, exhibiting a dose-dependent response within one hour of treatment. Furthermore, KB 5666 preserves microtubule-associated protein 2 immunoreactivity in CA1 pyramidal cells and maintains [3H]PDBu binding activity post-ischemia. These properties make KB 5666 a valuable reagent for studying ischemic conditions and their cellular consequences in neurological research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
