Product Data Sheet
3-Oxochol-5-en-24-oic acid
Catalog No. A74008
3-Oxochol-5-en-24-oic acid is a potent antagonist of the human androgen receptor (hAR) with an IC50 value of 119.4 nM. This bile acid, produced by the intestinal microbiota, demonstrates significant inhibitory effects on prostate cancer cell growth. Additionally, it enhances the efficacy of anti-PD-1 therapy in animal models by modulating the differentiation of CD8+ T cells. 3-Oxochol-5-en-24-oic acid is valuable for research into host immunity regulation and anti-tumor mechanisms.
Chemical Information
| Catalog Num | A74008 |
|---|---|
| M. Wt | 372.54 |
| Formula | C24H36O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 847232-54-6 |
| Synonyms | |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)=O)=CC3)C |
Biological Activity
| Description | 3-Oxochol-5-en-24-oic acid is a potent antagonist of the human androgen receptor (hAR) with an IC50 value of 119.4 nM. This bile acid, produced by the intestinal microbiota, demonstrates significant inhibitory effects on prostate cancer cell growth. Additionally, it enhances the efficacy of anti-PD-1 therapy in animal models by modulating the differentiation of CD8+ T cells. 3-Oxochol-5-en-24-oic acid is valuable for research into host immunity regulation and anti-tumor mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
