Product Data Sheet
KRP-109
Catalog No. A74122
KRP-109 is a potent inhibitor of neutrophil elastase (NE), demonstrating significant activity in mitigating lung inflammation. In mouse models, KRP-109 has been shown to enhance survival rates and decrease neutrophil accumulation within the alveolar walls. This compound effectively reduces cell and neutrophil counts in bronchoalveolar lavage fluid, as well as lowers levels of pro-inflammatory cytokines, including interleukin 1β and macrophage inflammatory protein 2. KRP-109 is valuable for research focused on severe pneumonia and associated inflammatory conditions.
Chemical Information
| Catalog Num | A74122 |
|---|---|
| M. Wt | 510.54 |
| Formula | C26H30N4O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1275996-50-3 |
| Synonyms | |
| SMILES | OC(/C=C\C(O)=O)=O.CCC1=C2C(N=C(C3=C(N4C[C@H](CC4)N(C)C)N=CC=C3)OC2=O)=CC(OC)=C1 |
Biological Activity
| Description | KRP-109 is a potent inhibitor of neutrophil elastase (NE), demonstrating significant activity in mitigating lung inflammation. In mouse models, KRP-109 has been shown to enhance survival rates and decrease neutrophil accumulation within the alveolar walls. This compound effectively reduces cell and neutrophil counts in bronchoalveolar lavage fluid, as well as lowers levels of pro-inflammatory cytokines, including interleukin 1β and macrophage inflammatory protein 2. KRP-109 is valuable for research focused on severe pneumonia and associated inflammatory conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
