Product Data Sheet
NE58018
Catalog No. A74318
NE58018 is a potent inhibitor of bone resorption, primarily targeting Farnesyl pyrophosphate synthase (FPPS). This compound demonstrates enhanced inhibitory activity due to its structural features and the presence of aminophosphonates. NE58018 modulates the interactions of Thr201 and Tyr204 residues, which are critical for substrate binding and catalysis, thereby increasing the overall inhibition of FPPS. It is useful in research related to bone metabolism and related disorders.
Chemical Information
| Catalog Num | A74318 |
|---|---|
| M. Wt | 283.11 |
| Formula | C7H11NO7P2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 105462-23-5 |
| Synonyms | |
| SMILES | OC([P](O)(O)=O)([P](O)(O)=O)CC1=CC=CC=N1 |
Biological Activity
| Description | NE58018 is a potent inhibitor of bone resorption, primarily targeting Farnesyl pyrophosphate synthase (FPPS). This compound demonstrates enhanced inhibitory activity due to its structural features and the presence of aminophosphonates. NE58018 modulates the interactions of Thr201 and Tyr204 residues, which are critical for substrate binding and catalysis, thereby increasing the overall inhibition of FPPS. It is useful in research related to bone metabolism and related disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
