Product Data Sheet
Scio-323
Catalog No. A74368
Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism.
Chemical Information
| Catalog Num | A74368 |
|---|---|
| M. Wt | 479.54 |
| Formula | C27H30FN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 309913-51-7 |
| Synonyms | |
| SMILES | O=C(C1=CN(C)C2=C1C=C(C(N3CCC(CC3)CC4=CC=C(C=C4)F)=O)C(OC)=C2)C(N(C)C)=O |
Biological Activity
| Description | Scio-323 is an orally active inhibitor of the p38 mitogen-activated protein kinase (MAPK), primarily targeting chronic inflammatory responses linked to polyethylene particles. This compound has demonstrated the ability to reduce inflammation; however, it shows minimal impact on bone formation during such responses. Notably, Scio-323 treatment does not enhance bone growth in the presence of polyethylene particles, and osteoblast-like activity remains suppressed. This positions Scio-323 as a significant candidate for research into chronic inflammatory conditions affecting bone metabolism. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
