Product Data Sheet
Norharman-d7
Catalog No. A74470
Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology.
Chemical Information
| Catalog Num | A74470 |
|---|---|
| M. Wt | 175.24 |
| Formula | C11HD7N2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1216503-21-7 |
| Synonyms | |
| SMILES | [2H]C1=C(C([2H])=C(C2=C1C3=C(C([2H])=NC([2H])=C3[2H])N2)[2H])[2H] |
Biological Activity
| Description | Norharman-d7 is a deuterium-labeled derivative of Norharmane, a β-carboline alkaloid known for its reversible inhibition of monoamine oxidase (MAO). It exhibits notable biological activity as an antidepressant, with IC50 values of 6.5 μM for MAO-A and 4.7 μM for MAO-B, and demonstrates potential as an anti-cancer photosensitizer. Additionally, Norharmane-d7 influences polar auxin transport by inhibiting transport proteins PIN2, PIN3, and PIN7, significantly affecting the growth of Arabidopsis thaliana seedlings, making it valuable for research in neurochemistry and plant biology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
