Product Data Sheet
Ercalcitriol-d3
Catalog No. A74471
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms.
Chemical Information
| Catalog Num | A74471 |
|---|---|
| M. Wt | 431.67 |
| Formula | C28H41D3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1261254-46-9 |
| Synonyms | 1α,25-Dihydroxy Vitamin D2-d3 |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(C)(O)C)([H])/C(CCC1)=C/C([2H])=C3\C([C@H](C[C@@H](C3)O)O)=C([2H])/[2H] |
Biological Activity
| Description | Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is a deuterium-labeled analog of Ercalcitriol, a potent vitamin D receptor (VDR) agonist with high affinity for VDR. Upon binding, Ercalcitriol-d3 interacts with retinoid X receptor (RXR) to modulate gene transcription, leading to increased expression of antimicrobial peptides, such as human cat antimicrobial peptide (hCAP-18/LL-37), which is effective against periodontal pathogens like Porphyromonas gingivalis. This reagent is primarily utilized in research studies focused on periodontal diseases and immune-related conditions of the oral cavity, enhancing understanding of immune defense mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
