Product Data Sheet
Edoxaban-d6
Catalog No. A74703
Edoxaban-d6 is a deuterium-labeled derivative of Edoxaban, a selective and potent inhibitor of factor Xa (FXa). Edoxaban exhibits high affinity for FXa with an IC50 of 0.561 nM, making it an effective anticoagulant for stroke prevention. It also displays weak inhibitory activity against thrombin and factor IXaβ, while maintaining a selectivity of over 10,000-fold for FXa. This reagent is useful for studying antithrombotic mechanisms and evaluating treatments for thromboembolic diseases in a variety of research applications.
Chemical Information
| Catalog Num | A74703 |
|---|---|
| M. Wt | 554.09 |
| Formula | C24H24D6ClN7O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1304701-57-2 |
| Synonyms | DU-176-d6 |
| SMILES | O=C(C1=NC2=C(CN(CC2)C)S1)N[C@H]3[C@H](CC[C@@H](C3)C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)NC(C(NC4=CC=C(C=N4)Cl)=O)=O |
Biological Activity
| Description | Edoxaban-d6 is a deuterium-labeled derivative of Edoxaban, a selective and potent inhibitor of factor Xa (FXa). Edoxaban exhibits high affinity for FXa with an IC50 of 0.561 nM, making it an effective anticoagulant for stroke prevention. It also displays weak inhibitory activity against thrombin and factor IXaβ, while maintaining a selectivity of over 10,000-fold for FXa. This reagent is useful for studying antithrombotic mechanisms and evaluating treatments for thromboembolic diseases in a variety of research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
