Product Data Sheet
HEC96719
Catalog No. A74882
HEC96719 is a selective tricyclic agonist of the farnesoid X receptor (FXR) that demonstrates potent activity with EC50 values of 1.37 nM and 1.55 nM in time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively. This compound has shown significant efficacy in improving non-alcoholic steatohepatitis (NASH) and liver fibrosis, exhibiting favorable distribution in liver and intestinal tissues. HEC96719 is valuable for research focusing on non-alcoholic steatohepatitis and related liver conditions.
Chemical Information
| Catalog Num | A74882 |
|---|---|
| M. Wt | 549.40 |
| Formula | C29H22Cl2N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2181834-03-5 |
| Synonyms | |
| SMILES | O=C(C1=CC=C2C(OC3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)N=C3C7(CC7)C2)=C1)O |
Biological Activity
| Description | HEC96719 is a selective tricyclic agonist of the farnesoid X receptor (FXR) that demonstrates potent activity with EC50 values of 1.37 nM and 1.55 nM in time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively. This compound has shown significant efficacy in improving non-alcoholic steatohepatitis (NASH) and liver fibrosis, exhibiting favorable distribution in liver and intestinal tissues. HEC96719 is valuable for research focusing on non-alcoholic steatohepatitis and related liver conditions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
