Product Data Sheet
BMS-986318
Catalog No. A74887
BMS-986318 is a potent non-bile acid agonist of the farnesoid X receptor (FXR), exhibiting EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. This compound possesses a favorable ADME profile and has demonstrated efficacy in preclinical models of liver cholestasis and fibrosis, particularly in mouse bile duct ligation studies. BMS-986318 is suitable for research related to nonalcoholic steatohepatitis and its potential therapeutic implications.
Chemical Information
| Catalog Num | A74887 |
|---|---|
| M. Wt | 615.43 |
| Formula | C30H23Cl2F3N4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2314378-09-9 |
| Synonyms | |
| SMILES | O=C(C1=CC(C(F)(F)F)=C2C=C(N3CCC4(CC3)C=C(C4)C5=C(C6CC6)ON=C5C7=C(Cl)C=NC=C7Cl)C=CC2=N1)O |
Biological Activity
| Description | BMS-986318 is a potent non-bile acid agonist of the farnesoid X receptor (FXR), exhibiting EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. This compound possesses a favorable ADME profile and has demonstrated efficacy in preclinical models of liver cholestasis and fibrosis, particularly in mouse bile duct ligation studies. BMS-986318 is suitable for research related to nonalcoholic steatohepatitis and its potential therapeutic implications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
