Product Data Sheet
LZ-007
Catalog No. A74893
LZ-007 is a highly selective agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 51 nM in TR-FRET assays and 76 nM in HepG2 cells. This compound demonstrates favorable pharmacokinetic properties in SD rats. LZ-007 has shown efficacy in ameliorating metabolic dysfunction associated with steatohepatitis in models of western diet and CCl4-induced mice, making it a valuable tool for research in metabolic diseases and liver dysfunction.
Chemical Information
| Catalog Num | A74893 |
|---|---|
| M. Wt | 518.52 |
| Formula | C27H29F3N2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2920000-23-1 |
| Synonyms | |
| SMILES | CC(C)C1=C(CN2CCC(COC3=CC=C(C(O)=O)C=C3)CC2)C(C4=CC=CC=C4OC(F)(F)F)=NO1 |
Biological Activity
| Description | LZ-007 is a highly selective agonist of the farnesoid X receptor (FXR), exhibiting an EC50 of 51 nM in TR-FRET assays and 76 nM in HepG2 cells. This compound demonstrates favorable pharmacokinetic properties in SD rats. LZ-007 has shown efficacy in ameliorating metabolic dysfunction associated with steatohepatitis in models of western diet and CCl4-induced mice, making it a valuable tool for research in metabolic diseases and liver dysfunction. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
