Product Data Sheet
2-Oxokolavenol
Catalog No. A74898
2-Oxokolavenol is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of approximately 3.7 μM. This compound mitigates acetaminophen-induced hepatocyte damage through an FXR-dependent mechanism, facilitating the recruitment of co-activators and enhancing FXR transcriptional activity. Derived from the plant Aglaia spectabilis, 2-Oxokolavenol is valuable for research on liver diseases and the underlying mechanisms of FXR signaling.
Chemical Information
| Catalog Num | A74898 |
|---|---|
| M. Wt | 304.47 |
| Formula | C20H32O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 130395-82-3 |
| Synonyms | |
| SMILES | O=C1C[C@]2([H])[C@@](C)(CC/C(C)=C/CO)[C@H](C)CC[C@@]2(C)C(C)=C1 |
Biological Activity
| Description | 2-Oxokolavenol is a selective agonist of the farnesoid X receptor (FXR), demonstrating an EC50 of approximately 3.7 μM. This compound mitigates acetaminophen-induced hepatocyte damage through an FXR-dependent mechanism, facilitating the recruitment of co-activators and enhancing FXR transcriptional activity. Derived from the plant Aglaia spectabilis, 2-Oxokolavenol is valuable for research on liver diseases and the underlying mechanisms of FXR signaling. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
