Product Data Sheet
PX20350
Catalog No. A74902
PX20350 is an FXR (Farnesoid X receptor) agonist, exhibiting EC50 values of 83 nM and 10 nM for mouse and human FXR, respectively. This compound significantly induces the expression of NDRG2 mRNA and demonstrates potent anti-tumor activity by inhibiting the growth and metastasis of liver tumor cells, specifically SK-GI-18. Additionally, PX20350 has been shown to possess anti-tumorigenic effects in orthotopic xenograft mouse models, making it valuable for investigating liver cancer biology and therapeutic strategies.
Chemical Information
| Catalog Num | A74902 |
|---|---|
| M. Wt | 592.39 |
| Formula | C28H22Cl2F3N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1198085-23-2 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(CN(C)C2=CC=C(OCC3=C(C4CC4)ON=C3C5=C(Cl)C=CC=C5Cl)N=C2C(F)(F)F)C=C1)O |
Biological Activity
| Description | PX20350 is an FXR (Farnesoid X receptor) agonist, exhibiting EC50 values of 83 nM and 10 nM for mouse and human FXR, respectively. This compound significantly induces the expression of NDRG2 mRNA and demonstrates potent anti-tumor activity by inhibiting the growth and metastasis of liver tumor cells, specifically SK-GI-18. Additionally, PX20350 has been shown to possess anti-tumorigenic effects in orthotopic xenograft mouse models, making it valuable for investigating liver cancer biology and therapeutic strategies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
