Product Data Sheet
FXR agonist 16
Catalog No. A74909
FXR Agonist 16 is a potent FXR agonist with an EC50 of 2.2 μM, effectively activating FXR transcriptional activity. This compound upregulates small heterodimer partner (SHP) and bile salt export pump (BSEP) while downregulating cytochrome P450 7A1 (Cyp7a1), which contributes to its hepatoprotective properties. FXR Agonist 16 is valuable for research focused on liver injury, demonstrating a reduction in serum AST and ALT levels in models of free fatty acid-induced hepatocellular damage.
Chemical Information
| Catalog Num | A74909 |
|---|---|
| M. Wt | 372.56 |
| Formula | C23H32O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3099198-78-1 |
| Synonyms | |
| SMILES | CC1(C)[C@]2([H])CC[C@]3(C)CCC[C@](C3)(SC4=C(C(OC)=O)C=CC=C4)[C@@]2([H])C1 |
Biological Activity
| Description | FXR Agonist 16 is a potent FXR agonist with an EC50 of 2.2 μM, effectively activating FXR transcriptional activity. This compound upregulates small heterodimer partner (SHP) and bile salt export pump (BSEP) while downregulating cytochrome P450 7A1 (Cyp7a1), which contributes to its hepatoprotective properties. FXR Agonist 16 is valuable for research focused on liver injury, demonstrating a reduction in serum AST and ALT levels in models of free fatty acid-induced hepatocellular damage. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
