Product Data Sheet
Dantrolene-13C3
Catalog No. A74992
Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome.
Chemical Information
| Catalog Num | A74992 |
|---|---|
| M. Wt | 317.23 |
| Formula | C1113C3H10N4O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1185234-99-4 |
| Synonyms | F 368-13C3 |
| SMILES | O=[13C](N[13C]1=O)[13CH2]N1/N=C/C2=CC=C(C3=CC=C(C=C3)[N+]([O-])=O)O2 |
Biological Activity
| Description | Dantrolene-13C3 is a stable isotope-labeled analog of Dantrolene, a muscle relaxant that non-competitively inhibits human erythrocyte glutathione reductase, with Ki and IC50 values of 111.6 μM and 52.3 μM, respectively. As a ryanodine receptor antagonist, Dantrolene-13C3 plays a critical role in stabilizing Ca2+ signaling. This reagent is suitable for research applications related to muscle spasticity, malignant hyperthermia, Huntington's disease, and neuroleptic malignant syndrome. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
