Product Data Sheet
Phorone
Catalog No. A74993
Phorone, a glutathione (GSH) depletor, functions by specifically and reversibly depleting free GSH through enzymatic interaction with glutathione S-transferase (Km = 0.9 mM). This compound has been demonstrated to reversibly affect the binding and nuclear uptake of glucocorticoid receptors in rat liver, correlating with fluctuations in GSH levels. Phorone is valuable for research focused on liver toxicity mechanisms and the role of oxidative stress in cellular dysfunction.
Chemical Information
| Catalog Num | A74993 |
|---|---|
| M. Wt | 138.21 |
| Formula | C9H14O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 504-20-1 |
| Synonyms | Diisopropylidene acetone |
| SMILES | O=C(/C=C(C)/C)/C=C(C)\C |
Biological Activity
| Description | Phorone, a glutathione (GSH) depletor, functions by specifically and reversibly depleting free GSH through enzymatic interaction with glutathione S-transferase (Km = 0.9 mM). This compound has been demonstrated to reversibly affect the binding and nuclear uptake of glucocorticoid receptors in rat liver, correlating with fluctuations in GSH levels. Phorone is valuable for research focused on liver toxicity mechanisms and the role of oxidative stress in cellular dysfunction. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
