Product Data Sheet
Migalastat
Catalog No. A75101
Migalastat is an orally active inhibitor of α-galactosidase A, functioning primarily as a molecular chaperone with an IC50 value of 0.04 μM for human α-Gal A. This compound selectively binds to the active site of specific unstable mutant forms of α-galactosidase A, promoting their proper transport to the lysosome. Upon dissociating in the acidic lysosomal environment, Migalastat enhances the biological activity of the mutant enzyme, making it a valuable tool in research related to lysosomal storage disorders.
Chemical Information
| Catalog Num | A75101 |
|---|---|
| M. Wt | 163.17 |
| Formula | C6H13NO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 108147-54-2 |
| Synonyms | GR181413A free base; 1-Deoxygalactonojirimycin |
| SMILES | O[C@H]1[C@@H](CO)NC[C@H](O)[C@H]1O |
Biological Activity
| Description | Migalastat is an orally active inhibitor of α-galactosidase A, functioning primarily as a molecular chaperone with an IC50 value of 0.04 μM for human α-Gal A. This compound selectively binds to the active site of specific unstable mutant forms of α-galactosidase A, promoting their proper transport to the lysosome. Upon dissociating in the acidic lysosomal environment, Migalastat enhances the biological activity of the mutant enzyme, making it a valuable tool in research related to lysosomal storage disorders. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
