Product Data Sheet
Zifcasiran sodium
Catalog No. A75525
Zifcasiran sodium is a synthetic double-stranded siRNA designed to target hypoxia-inducible factor-2α (HIF2α), modulating its expression and disrupting pro-oncogenic signaling pathways. This reagent effectively engages the RNA interference (RNAi) machinery, facilitating the degradation of HIF2α (EPAS1) mRNA, which leads to a decrease in translated HIF2α protein levels. Zifcasiran sodium is particularly relevant in research focused on clear cell renal cell carcinoma (ccRCC) and the mechanisms of tumor growth regulation.
Chemical Information
| Catalog Num | A75525 |
|---|---|
| M. Wt | 21491.26 |
| Formula | C737H929F20N211Na52O349P43S8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2437257-12-8 |
| Synonyms | ADS-007 sodium; ARO HIF2 sodium |
| SMILES | [Zifcasiran (sodium)] |
Biological Activity
| Description | Zifcasiran sodium is a synthetic double-stranded siRNA designed to target hypoxia-inducible factor-2α (HIF2α), modulating its expression and disrupting pro-oncogenic signaling pathways. This reagent effectively engages the RNA interference (RNAi) machinery, facilitating the degradation of HIF2α (EPAS1) mRNA, which leads to a decrease in translated HIF2α protein levels. Zifcasiran sodium is particularly relevant in research focused on clear cell renal cell carcinoma (ccRCC) and the mechanisms of tumor growth regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
