Product Data Sheet
HIF-1α-IN-2
Catalog No. A75534
HIF-1α-IN-2 is a potent inhibitor of HIF-1α, demonstrating significant anticancer activity with IC50 values of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cell lines, respectively. This compound functions by inhibiting the transcription and translation of HIF-1α, effectively suppressing its expression. HIF-1α-IN-2 is applicable in research exploring hypoxia-induced tumor progression and therapeutic resistance in cancer studies.
Chemical Information
| Catalog Num | A75534 |
|---|---|
| M. Wt | 361.46 |
| Formula | C21H19N3OS |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2762315-06-8 |
| Synonyms | |
| SMILES | CC1=NC(C2=CC(NC3=CC(C)=NC4=CC(OC)=CC=C34)=CC=C2)=CS1 |
Biological Activity
| Description | HIF-1α-IN-2 is a potent inhibitor of HIF-1α, demonstrating significant anticancer activity with IC50 values of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cell lines, respectively. This compound functions by inhibiting the transcription and translation of HIF-1α, effectively suppressing its expression. HIF-1α-IN-2 is applicable in research exploring hypoxia-induced tumor progression and therapeutic resistance in cancer studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
