Product Data Sheet
GSK360A
Catalog No. A75541
GSK360A is a potent and orally bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD) with IC50 values of 10 nM, 100 nM, and 126 nM for PHD1, PHD2, and PHD3, respectively. This compound effectively activates the HIF-1 alpha signaling pathway, providing protective effects on the heart in the context of myocardial infarction (MI). GSK360A holds potential for advancing therapeutic strategies in cardiovascular research and conditions related to oxygen deprivation.
Chemical Information
| Catalog Num | A75541 |
|---|---|
| M. Wt | 348.33 |
| Formula | C17H17FN2O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 931399-19-8 |
| Synonyms | |
| SMILES | O=C(CNC(C1=C(C2=C(C=CC(F)=C2)N(C1=O)CCC3CC3)O)=O)O |
Biological Activity
| Description | GSK360A is a potent and orally bioavailable inhibitor of hypoxia-inducible factor prolyl hydroxylases (HIF-PHD) with IC50 values of 10 nM, 100 nM, and 126 nM for PHD1, PHD2, and PHD3, respectively. This compound effectively activates the HIF-1 alpha signaling pathway, providing protective effects on the heart in the context of myocardial infarction (MI). GSK360A holds potential for advancing therapeutic strategies in cardiovascular research and conditions related to oxygen deprivation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
