Product Data Sheet
KG-548
Catalog No. A75542
KG-548 is a potent HIF-1α/β inhibitor that disrupts the ARNT/TACC3 complex formation by competitively binding to the ARNT PAS-B domain. By inhibiting the interaction between ARNT (aryl hydrocarbon receptor nuclear translocator) and TACC3, KG-548 plays a crucial role in modulating hypoxia-inducible factor pathways. This compound is valuable for research applications focused on cancer biology, metabolism, and hypoxic tumor microenvironments.
Chemical Information
| Catalog Num | A75542 |
|---|---|
| M. Wt | 282.15 |
| Formula | C9H4F6N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 175205-09-1 |
| Synonyms | |
| SMILES | FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F |
Biological Activity
| Description | KG-548 is a potent HIF-1α/β inhibitor that disrupts the ARNT/TACC3 complex formation by competitively binding to the ARNT PAS-B domain. By inhibiting the interaction between ARNT (aryl hydrocarbon receptor nuclear translocator) and TACC3, KG-548 plays a crucial role in modulating hypoxia-inducible factor pathways. This compound is valuable for research applications focused on cancer biology, metabolism, and hypoxic tumor microenvironments. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
