Product Data Sheet
NVP-DFF332
Catalog No. A75555
NVP-DFF332 is a potent HIF2α inhibitor that demonstrates inhibitory activity with IC50 values of 9 nM for HIF2α SPA, 37 nM for HIF2α iScript, and 246 nM for HIF2α HRE RGA. This compound exhibits significant antitumor effects, making it valuable for cancer research focused on hypoxia-inducible factors. Its ability to modulate HIF2α activity positions NVP-DFF332 as a promising tool for studying tumor biology and therapeutic interventions.
Chemical Information
| Catalog Num | A75555 |
|---|---|
| M. Wt | 441.73 |
| Formula | C17H11ClF7N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2734922-78-0 |
| Synonyms | HIF-2α-IN-8 |
| SMILES | FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F |
Biological Activity
| Description | NVP-DFF332 is a potent HIF2α inhibitor that demonstrates inhibitory activity with IC50 values of 9 nM for HIF2α SPA, 37 nM for HIF2α iScript, and 246 nM for HIF2α HRE RGA. This compound exhibits significant antitumor effects, making it valuable for cancer research focused on hypoxia-inducible factors. Its ability to modulate HIF2α activity positions NVP-DFF332 as a promising tool for studying tumor biology and therapeutic interventions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
