Product Data Sheet
Zifcasiran
Catalog No. A75571
Zifcasiran is a synthetic double-stranded siRNA designed to target hypoxia-inducible factor-2 alpha (HIF2α). By engaging the RNA interference (RNAi) pathway, Zifcasiran effectively degrades HIF2α mRNA, thereby inhibiting the expression of this key oncogenic factor in clear cell renal cell carcinoma (ccRCC). This mechanism reduces downstream pro-oncogenic signaling, making Zifcasiran a valuable tool for research on ccRCC and potential therapeutic applications in targeting hypoxia-related pathways.
Chemical Information
| Catalog Num | A75571 |
|---|---|
| M. Wt | 20339.13 |
| Formula | C737H972F20N211O349P43S8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2437257-11-7 |
| Synonyms | ADS-007; ARO HIF2 |
| SMILES | [Zifcasiran] |
Biological Activity
| Description | Zifcasiran is a synthetic double-stranded siRNA designed to target hypoxia-inducible factor-2 alpha (HIF2α). By engaging the RNA interference (RNAi) pathway, Zifcasiran effectively degrades HIF2α mRNA, thereby inhibiting the expression of this key oncogenic factor in clear cell renal cell carcinoma (ccRCC). This mechanism reduces downstream pro-oncogenic signaling, making Zifcasiran a valuable tool for research on ccRCC and potential therapeutic applications in targeting hypoxia-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
