Product Data Sheet
103D5R
Catalog No. A75579
103D5R is a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) activation, exhibiting an IC50 of 35 µM through the suppression of HIF-1α protein synthesis. This compound also inhibits the proliferation of LN229 cells, with an IC50 of 26 µM, making it a valuable tool for research into tumor biology and the molecular mechanisms of hypoxia. Its applications extend to studies exploring the role of HIF-1 in cancer progression and therapy resistance.
Chemical Information
| Catalog Num | A75579 |
|---|---|
| M. Wt | 335.40 |
| Formula | C20H21N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 773852-25-8 |
| Synonyms | |
| SMILES | CC(N1C=NC2=NC=CC=C21)C3=CC=C4C(C=CC(C)(C)O4)=C3OC |
Biological Activity
| Description | 103D5R is a potent inhibitor of hypoxia-inducible factor-1 (HIF-1) activation, exhibiting an IC50 of 35 µM through the suppression of HIF-1α protein synthesis. This compound also inhibits the proliferation of LN229 cells, with an IC50 of 26 µM, making it a valuable tool for research into tumor biology and the molecular mechanisms of hypoxia. Its applications extend to studies exploring the role of HIF-1 in cancer progression and therapy resistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
