Product Data Sheet
KST012174 hydrochloride
Catalog No. A75598
KST012174 hydrochloride is a selective inhibitor of the HIF-1α-p300/CBP interaction, demonstrating an IC50 of 107 μM. It effectively disrupts the binding of HIF-1α to the p300 protein at concentrations of 100 μM without altering HIF-1α protein stability. By targeting the C-terminal transactivation domain of HIF-1α and the CH1 domain of p300, KST012174 hydrochloride inhibits HIF-1α-mediated transcriptional activation, leading to decreased VEGF mRNA expression and suppression of tumor angiogenesis. This reagent is valuable for research into cancer biology and hypoxia-related pathways.
Chemical Information
| Catalog Num | A75598 |
|---|---|
| M. Wt | 545.50 |
| Formula | C27H34Cl2N6O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1392224-35-9 |
| Synonyms | |
| SMILES | O=C(N1CCN(CC1)CC(NC2=C(Cl)C=CC=C2)=O)NCC3=NN(C(CC(C)C)=C3)C4=CC=CC=C4.Cl |
Biological Activity
| Description | KST012174 hydrochloride is a selective inhibitor of the HIF-1α-p300/CBP interaction, demonstrating an IC50 of 107 μM. It effectively disrupts the binding of HIF-1α to the p300 protein at concentrations of 100 μM without altering HIF-1α protein stability. By targeting the C-terminal transactivation domain of HIF-1α and the CH1 domain of p300, KST012174 hydrochloride inhibits HIF-1α-mediated transcriptional activation, leading to decreased VEGF mRNA expression and suppression of tumor angiogenesis. This reagent is valuable for research into cancer biology and hypoxia-related pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
