Product Data Sheet
CHNQD-03301
Catalog No. A75605
CHNQD-03301 is a potent orally active inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α) with an IC50 value of 10.97 nM. This compound induces proteasomal degradation of HIF-1α, effectively suppressing its accumulation. CHNQD-03301 has demonstrated the ability to reverse angiogenesis induced by HIF accumulation and reduce the HIF-driven erythrocytosis phenotype in zebrafish models. It is a valuable tool for investigating HIF-1α-related processes in colon cancer research.
Chemical Information
| Catalog Num | A75605 |
|---|---|
| M. Wt | 392.40 |
| Formula | C23H20O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3104302-65-7 |
| Synonyms | |
| SMILES | OC1=CC=C(C2=CC(OC)=C3C(OC4=CC(OC(C)(C)O5)=C5C=C34)=C2OC)C=C1 |
Biological Activity
| Description | CHNQD-03301 is a potent orally active inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α) with an IC50 value of 10.97 nM. This compound induces proteasomal degradation of HIF-1α, effectively suppressing its accumulation. CHNQD-03301 has demonstrated the ability to reverse angiogenesis induced by HIF accumulation and reduce the HIF-driven erythrocytosis phenotype in zebrafish models. It is a valuable tool for investigating HIF-1α-related processes in colon cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
